Gustometry in various variants of bronchial asthma: Sensitivity thresholds for bitter and sweet tast

The first studies were published on the possible pathogenetic role of so-called ectopically localized taste receptors in bronchial asthma. for bitter and sweet taste, may, apparently, have opposite functions, but available literature there is no data balance sensitivity tastes same patients with aim present work to simultaneously assess canonical lingual different clinical variants asthma by methods applicable wide practice. 16 healthy persons 35 examined at M.V. Chernorutsky Clinics Hospital Therapy First St. Petersburg State I. Pavlov Medical University. was assessed using Frey Scientific 569885 PTC Taste Paper test strip kit containing phenylthiourea solution. Sucrose solutions concentrations 0.3; 0,4; 0,5; 0,6; 0,7; 0,8; 0,9 % determination individual value thresholds used. bitter-to-sweet basis an original “bitter/sweet sensitivity” index. highest values index bitter/sweet found allergic variant asthma: its are significantly from those only low sucrose (0.3-0.4%). factor analysis revealed association between imbalance (a shift towards high taste) key characteristics asthma, including severity course, duration inhaled glucocorticosteroid use inefficiency β2-agonists pre-clinical stage. It has been gustometry that a decreased substance (phenylthiourea), along higher (sucrose).